This parish was formed by a merger of Sacred Heart, Our Lady of Perpetual Help and Precious Blood Parishes, Holyoke. These parishes were supressed and Our Lady of Guadalupe Parish erected by Episcopal Decree, March 1, 2001
Our Lady of Guadalupe Parish holds all the sacramental records of the above mentioned parishes. Also as part of the Parish are three cemeteries, Precious Blood, Notre-Dame and Saint Rose, all in South Hadley, Massachusetts. All records for these cemeteries are held by Our Lady of Gudalupe as well. The parish also posseses and administrates these cemeteries.